Why do alcoholic men develop so-called man boobs and other feminine traits? We know estrogens produce feminization, and our liver clears estrogens from the body. As such, the original theory was that alcohol-induced liver damage led to the retention of excess estrogens. The problem was that when researchers measured estrogen levels, they weren’t elevated. What’s more, even those with cirrhosis of the liver appeared to clear estrogens from the body normally, and men’s testicles started shrinking even before serious liver disease developed.
So, alternative explanations were considered. If it’s not due to estrogens produced endogenously, meaning within the body, maybe alcoholics are being exposed to “exogenous estrogenic substances from dietary sources”—perhaps from phytoestrogens in the plants that alcoholic beverages are made from. The discovery that plants could contain hormonal compounds was made back in 1951 by two Australian chemists charged with finding out the cause of an “epidemic of infertility in sheep that was ravaging their nation’s wool industry.” It took them ten years, but they finally figured out the cause: a compound called genistein, present in a type of clover, and the same phytoestrogen found in soybeans.
You can read about the dreaded clover disease on scare-mongering websites, but you’ll note they never talk about the difference in dose. To get as much as the sheep were getting from clover, you’d have to drink more than 1,000 cartons of soymilk a day or eat more than 8,000 soy burgers or about 800 pounds of tofu a day.
This is not to say you can’t overdo it. There are two case reports in the medical literature that describe feminizing effects associated with eating as few as 14 to 20 servings of soy foods a day. But at reasonable doses, or even considerably higher than the one or two servings a day Asian men eat, soy phytoestrogens do not exert feminizing effects on men.
So, back in 1951, we realized plant compounds could be estrogenic. Two German researchers realized that perhaps that’s why women who handle hops start menstruating, and, indeed, they found estrogenic activity in hops, which is the bittering agent used to make beer. They found trace amounts of the soy phytoestrogens, but in such tiny quantities that beer would not be expected to have an estrogenic effect. In 1999, however, a potent phytoestrogen called 8-prenylnaringenin was discovered in hops, which I discuss in my video The Most Potent Phytoestrogen Is in Beer. In fact, it’s the most potent phytoestrogen found to date, fifty times more potent than the genistein in soy, “provid[ing] an obvious explanation for the menstrual disturbances in female hop workers in the past.” Today, we have machines to pick our hops, so our only exposure is likely via beer consumption, but the levels in beer were found to be so low that they shouldn’t cause any concern.
Then in 2001, a study on a hops-containing “dietary supplement for breast enhancement” raised the concern that another phytoestrogen in hops called isoxanthohumol might be biotransformed by our liver into the more potent 8-PN, which would greatly augment the estrogenic effect of hops. This study was conducted on mice, though. Thankfully, a study using human estrogen receptors found no such liver transformation, so all seemed fine…until 2005. “[T] he liver is not the only transformation site inside the human body.” The human colon contains trillions of microorganisms with enormous metabolic potential. It’s like a whole separate organ within our body, with a hundred livers’ worth of metabolizing power. So, let’s effectively mix some beer with some poop and see what happens.
Indeed, up to a 90 percent conversion was achieved. Up to then, “the concentration of 8-PN in beer was considered too low to affect human health. However, these results show that the activity of the intestinal microbial community could more than 10-fold increase the exposure concentration.” This can explain why you can detect 8-PN in the urine of beer-drinkers for days: Their gut bacteria keep churning it out. Obviously, the amount of straight 8-PN in beer is not the only source of estrogen effects given this conversion. So, a decade ago, the question remained: Might drinking too much beer cause estrogenic effects and feminize men? See my video What Are the Effects of the Hops Phytoestrogen in Beer? for the update.
29.05.-02.06.2019 in Schwäbisch Gmünd
Zeitraum: 07.-20. August 2019 (inkl. An- und Abreise)
Einsatzgebiet: Xaixai (gesprochen: Schaischai) und Umgebung, im Süden von Mosambik
Landessprache: Portugiesisch, es wird vor Ort möglich sein DEUTSCH zu sprechen, da wir Übersetzer haben werden.
1. Training am Vormittag (theoretische Schulung im Bereich Mission).
2. Gesundheitsarbeit (geringfügige kostenlose medizinische Behandlungen und Beratung in den Einsatzgebieten als Werbung für die Abendveranstaltungen. Findet an Nachmittagen statt.
3. Evangelistische Verkündigung an den Abenden. Teams von 3 Personen arbeiten in Einsatzgebieten mit Kindern (Kinderprogramm/ Kindergeschichte, Gesundheits- Kurzvorträge, Predigt). Alle Vortrags-Materialien sind schon bereit zur Nutzung.
Nach der Taufe am 17. August reisen wir am Sonntag ab zum Krüger-Nationalpark. Rückflug ist am Dienstag, 20.08.2019.
Es ist durchaus möglich privat länger zu bleiben und sich die Schönheit Südafrikas anzusehen.
The holiday season is strange. It’s filled with happy things, like food, family, and fun, but as the season grows colder and darker, and the holidays throw your schedule off kilter, you end up getting out of whack, too. Exercise gets put off until the New Year when you realize that a whole ‘nother year has passed, and you haven’t made any progress – or worse, you’ve gone backward – on your health goals. Well, I’m here to tell you that this doesn’t have to be the case. There are some secrets to exercising in the winter.
Okay, I’ll admit I did click bait you just a little with the title of this post. There is no secret, per se, to getting good exercise in winter. First off it’s not just one secret, but several. Also, the secrets are not bound by any season. Excuses like, “it’s too cold today,” or “it’s too dark outside,” or “I’m too busy” are just that: excuses. They can be and are used all year-round. The same goes for the “secrets” I’m about to share – they can be used all year-round, too.
So listen up. These principles will help you exercise regularly, regardless of location, people, time, climate, and virtually any other excuse for not exercising.
1. What is your “why”?
The biggest reason people don’t exercise is because they cannot find a good enough reason to do it. It may sound too simple to be true but please read on, because it’s true. If the reason isn’t important to you, you’re not going to spend the time and effort on it.
There’s a flip side to this. Nowadays, medical care is so good that a lot of people just don’t care about their health. They think, when I have my heart attack they’ll just put one of those stent things in me through my wrist and I’ll go home in a day. As a cardiologist, I see this all the time. Years ago, heart attack patients used to have to be placed under medical care for months. (The medical community stopped requiring this after many of those patients died from blood clots from inactivity). When I was in training to be a cardiologist, the typical stay after a heart attack was one week. In the past twenty years, that has dropped down to just 48 hours for an uncomplicated heart attack! It’s no wonder people don’t worry about their health – it just doesn’t seem as serious as it did before!