Long-term daily multivitamin supplement use may lower cataract risk in men, according to a study of nearly 15,000 male physicians published this month in Ophthalmology, the journal of the American Academy of Ophthalmology.
Researchers also find a slight, though statistically non-significant, increase in age-related macular degeneration risk among multivitamin users; call for further study.
Past observational studies have indicated a relationship between nutritional supplement use and eye health. However, randomized trial data on the effects of long-term multivitamin supplement use and risk of eye diseases are limited and, in some cases, non-existent. To address this, researchers based at Brigham and Women’s Hospital and Harvard Medical School – as part of the Physicians’ Health Study II (PHS II) – conducted a randomized, double-blind study from 1997 to 2011 of 14,641 U.S. male doctors age 50 and older. Half took a common daily multivitamin, as well as vitamin C, vitamin E and beta carotene supplements. The other half took a placebo.