How can we conquer one of the most tragic conditions ?
William Li presents a new way to think about treating cancer and other diseases: anti-angiogenesis, preventing the growth of blood vessels that feed a tumor. The crucial first (and best) step: Eating cancer-fighting foods that cut off the supply lines and beat cancer at its own game. Witness William Li’s interesting talk at TED (c).
In medicine, there is often the concern that a patient will not respond to a particular treatment, but in a turn for the books, physicians are now worried that a new cancer treatment might be so effective at eliminating tumors that it does more harm than good.After receiving a single treatment of a novel combination therapy, a woman’s tumor seemingly “dissolved” from her chest in just three weeks, leaving her with a gaping hole in its place. The patient received the same cocktail of skin cancer drugs as almost 150 individuals enrolled in a clinical trial designed to test whether one of the therapies worked better on its own or when combined with another. While most patients did significantly better on the combination therapy, researchers were left gobsmacked by this woman’s rapid and dramatic response and have consequently described her case in the New England Journal of Medicine, alongside the trial results.The therapies the scientists were investigating were the FDA-approved melanoma drugs Yervoy (ipilimumab) and Opdivo (nivolumab), which are both antibodies …
CHURCH PLACES STRONG EMPHASIS ON HEALTH AND WELLBEING
March 16, 2015 | Silver Spring, Maryland, United States | Andrew McChesney/Adventist Review
The Seventh-day Adventist Church has issued an official statement on vaccines, saying it “encourages responsible immunization” and has no faith-based reason to discourage believers from participating in immunization programs.
Image courtesy Wikimedia Commons
The full statement, titled, “Immunization,” says:
“The Seventh-day Adventist Church places strong emphasis on health and well-being. The Adventist health emphasis is based on biblical revelation, the inspired writing of E.G. White (co-founder of the church), and on peer-reviewed scientific literature. As such, we encourage responsible immunization/vaccination, and have no religious or faith-based reason not to encourage our adherents to responsibly participate in protective and preventive immunization programs. We value the health and safety of the population, which includes the maintenance of ‘herd immunity.’
“We are not the conscience of the individual church member, and recognize individual choices. These are exercised by the individual. The choice not to be immunized is not and should not be seen as the dogma nor the doctrine of the Seventh-day Adventist Church.”
Heilstätten sind ein erfolgreiches Mittel, um alle Klassen der Bevölkerung zu erreichen. Unsre Krankenhäuser sind die rechte Hand des Evangeliums und öffnen Wege, auf denen leidende Menschen mit der frohen Botschaft der Heilung durch Christus erreicht werden.
[…] ER hat uns beauftragt, das von ihm begonnene Werk der ärztlichen Mission fortzuführen. […] Mir wurde besonders Licht darüber gegeben, dass viele Seelen in unsern Krankenhäusern die gegenwärtige Wahrheit annehmen und ihr folgen werden. In diesen Anstalten soll man Männer und Frauen lehren, wie sie für ihren Körper sorgen und gleichzeitig zum Glauben kommen können. Unsre Krankenhäuser sollen Schulen sein, in denen man auf dem Gebiet der ärztlichen Mission Unterricht erteilt. Sie sollen den sündenkranken Seelen die Blätter vom Lebensbaum darreichen, die ihnen Frieden, Hoffnung und Glauben an Jesus spenden. Quelle: Schatzkammer der Zeugnisse 3 S. 316, 317
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Medical missionary work is to be carried forward with an earnestness with which it has never yet been carried. This work is the door through which the truth is to find entrance to the large cities, and sanitariums are to be established in many places. Sanitarium work is one of the most successful means of reaching all classes of people. Our sanitariums are the right hand of the gospel, opening ways whereby suffering humanity may be reached with the glad tidings of healing through Christ.
[…] He has commissioned us to carry forward the medical missionary work that He began. […] I have been given special light that in our sanitariums many souls will receive and obey present truth. In these institutions men and women are to be taught how to care for their own bodies and at the same time how to become sound in the faith. Our sanitariums are to be schools in which instruction shall be given in medical missionary lines. They are to bring to sin-sick souls the leaves of the tree of life, which will restore to them peace and hope and faith in Christ Jesus. Source: Testimonies of the Church Vol 9, pg.167, 168
Older adults suffering from sleep disturbances are more likely to die by suicide than well-rested adults, according to a study. “This is important because sleep disturbances are highly treatable, yet arguably less stigmatizing than many other suicide risk factors,” noted the lead author of the study.
“This is important because sleep disturbances are highly treatable, yet arguably less stigmatizing than many other suicide risk factors,” said Rebecca Bernert, PhD, lead author of the study. Bernert is an instructor of psychiatry and behavioral sciences and director of the Suicide Prevention Research Laboratory at Stanford.
Bernert said older adults have disproportionately higher rates of suicide risk compared to other age groups, making suicide prevention in elderly populations a pressing public health challenge. Using data from an epidemiological study of 14,456 adults aged 65 and older, Bernert and her colleagues compared the sleep quality of 20 who died by suicide with the sleep patterns of 400 similar individuals over a 10-year period. They found that participants reporting poor sleep had a 1.4 times greater chance of death by suicide within a 10-year period than participants who reported sleeping well.
The study confirmed the relationship between depression and suicide risk, while also assessing poor sleep as an independent risk factor. “Our findings suggest that poor sleep quality may serve as a stand-alone risk factor for late-life suicide,” Bernert said. Surprisingly, the study found that, when comparing the two risk factors, poor sleep predicted risk better than depressive symptoms. The combination of poor sleep and depressed mood was the strongest predictor of suicide risk. “Suicide is the outcome of multiple, often interacting biological, psychological and social risk factors,” Bernert said. “Disturbed sleep stands apart as a risk factor and warning sign in that it may be undone, which highlights its importance as a screening tool and potential treatment target in suicide prevention. “Suicide is preventable,” she added. “Yet interventions for suicide prevention are alarmingly scarce.”
Bernert has two studies now underway testing the effectiveness of an insomnia treatment for the prevention of depression and suicidal behaviors. Most of the study’s suicide decedents were white men, which reflects a group at heightened risk for suicide in the general population, Bernert said, noting that additional research is needed to see if the correlation between disturbed sleep and suicide risk extends to women, minorities and younger adults or teenagers.
Scientists at A*STAR’s Singapore Immunology Network (SIgN) have discovered a new class of lipids in the leukemia cells that are detected by a unique group of immune cells. By recognizing the lipids, the immune cells stimulate an immune response to destroy the leukemia cells and suppress their growth. The newly identified mode of cancer cell recognition by the immune system opens up new possibilities for leukemia immunotherapy.
Leukemia is characterized by the accumulation of cancer cells originating from blood cells, in the blood or bone marrow. Current treatments for leukemia largely involve chemotherapy to eradicate all cancer cells, followed by stem cell transplants to restore healthy blood cells in the patients.
In a recent study reported in the Journal of Experimental Medicine (JEM) online, the team co-led by Dr Lucia Mori and Prof Gennaro De Libero identified a new class of lipids, methyl-lysophosphatidic acids (mLPA), which accumulate in leukemia cells. Following which, the team identified a specific group of immune cells, described as mLPA-specific T-cells that are capable of recognising the mLPA in the leukemia cells. The detection triggers an immune response that activates the T cells to kill the leukemia cells and limits cancer progression. The efficacy of the T cells in killing leukemia cells was also demonstrated in a mouse model of human leukemia.
Thus far, only proteins in cancer cells have been known to activate T cells. This study is a pioneer in its discovery of mLPA, and the specific T cells which can identify lipids expressed by cancer cells. Unlike proteins, lipids in cancer cells do not differ between individuals, indicating that the recognition of mLPA by mLPA-specific T-cells happens in all leukemia patients. This new mode of cancer cell recognition suggests that the T-cells can potentially be harnessed for a leukemia immunotherapy that is effective in all patients.
“The identification of mLPA and its role in activating specific T cells is novel. This knowledge not only sheds light on future leukemia studies, but also complements ongoing leukemia immunotherapy studies focusing on proteins in cancer cells,” said Dr Lucia Mori, Principal Investigator at SIgN. “Current treatments run the risk of failure due to re-growth of residual leukemia cells that survive after stem cell transplants. T-cell immunotherapy may serve as a complementary treatment for more effective and safer therapeutic approach towards leukemia.”
Professor Laurent Renia, Acting Executive Director of SIgN, said, “At SIgN, we study how the human immune system protects us naturally from infections. We engage in promising disease-specific research projects that ultimately pave the way for the development of treatments and drugs which can better combat these diseases. A pertinent example will be this study; this mode of immune recognition of leukemia cells is an insightful discovery that will create new opportunities for immunotherapy to improve the lives of leukemia patients.”
Erectile dysfunction is the recurrent or persistent inability to attain and/or maintain an erection in order for satisfactory sexual performance. It is present in up to 30 million men in the U.S. and approximately 100 million men worldwide. The U.S. has less than 8% of the world’s population, yet up to 30% of the impotence? We’re #1!
But hey, we’ve got red, white, and blue pills like Viagra. The problem is that the pills just cover up the symptoms of vascular disease and don’t do anything for the underlying pathology. Erectile dysfunction and our #1 killer, coronary artery disease, are just two manifestations of the same disease: inflamed, clogged, and crippled arteries, regardless of which organ it affects (See Survival of the Firmest: Erectile Dysfunction and Death).
Atherosclerosis is considered a systemic disorder that uniformly affects all major blood vessels in the body. Hardening of the arteries can lead to softening of the penis because stiffened arteries can’t relax, open wide, and let the blood flow. Thus erectile dysfunction may just be the flaccid “tip of an iceberg” in terms of a systemic disorder. For two-thirds of men showing up to emergency rooms for the first time with crushing chest pain, their penis had been trying to warn them for years that something was wrong with their circulation.
Why does it hit the penis first? Because the penile arteries in the penis are half the size of the coronary artery in our heart. So the amount of plaque we wouldn’t even feel in the heart could clog half the penile artery, causing symptomatic restriction in blood flow. That’s why erectile dysfunction has been called “penile angina.” In fact, by measuring blood flow in a man’s penis we can predict the results of his cardiac stress test with an accuracy of 80%. Male sexual function is like a penile stress test, a “window into the hearts of men.”
Forty percent of men over age forty have erectile dysfunction. 40 over 40. Men with erection difficulties in their 40s have a 50-fold increased risk of having a cardiac event (like sudden death). I said before that various things increase heart disease risk by 20% or 30%. That’s nearly 5000%, leading the latest review to ask, “is there any risk greater?” That’s because it’s not so much a risk factor for atherosclerosis as atherosclerosis itself. A man “with erectile dysfunction (even if he doesn’t have cardiac symptoms) should be considered a cardiac patient until proven otherwise.”
Erectile dysfunction is considered to be a cardiac equivalent; it’s a marker of the coronary artery one likely already has. Thus, there’s more to treating ED than establishing an erect penis; it offers an opportunity for reducing cardiovascular risk. The reason even young men should care about their cholesterol is because itpredicts erectile dysfunction later in life, which in turn predicts heart attacks, strokes, and a shortened lifespan.